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Thyroid Eye Disease (TED) is a progressive, potentially sight-threatening condition often linked with Graves’ disease and other forms of hyperthyroidism. For many, TED leads to bulging eyes, double vision, discomfort, and even permanent disfigurement. Today, thanks to advances in treatment, patients have a promising non-surgical option—Tepezza (teprotumumab)—now available for suitable candidates.1

What is Thyroid Eye Disease (TED)?

TED occurs when the immune system mistakenly targets tissues around the eyes, leading to inflammation, swelling, and tissue re-modeling. Common symptoms include:1

  • Red, swollen, and bulging eyes
  • Double vision
  • Light sensitivity
  • Eye pain and discomfort

If you’ve been diagnosed with an overactive thyroid or Graves’ disease, it’s important to recognize these symptoms and seek prompt assessment.

How Does Tepezza Work?

Tepezza is a biologic medication that is Health Canada and FDA approved for specifically treating TED. It works by blocking the insulin-like growth factor-1 receptor (IGF-1R), a protein that drives inflammation and tissue growth in TED. By binding to IGF-1R, Tepezza can reduce swelling, bulging (proptosis), redness, pain, and double vision—addressing both the underlying disease process and the visible symptoms.2​

  • Treatment involves eight IV infusions over 24 weeks, with proven reductions in eye bulging (≥2 mm), double vision, and quality-of-life scores for most patients.2

Who is Eligible for Tepezza?

Tepezza is approved for adults with TED, regardless of how long they’ve had symptoms or the current activity level of their disease, making it appropriate for many who were previously only offered surgery or had limited options. Most studies support its use for both newly diagnosed and chronic TED patients.3

Clinical Benefits and Safety

  • Up to 83% of patients in clinical studies saw major improvement in bulging eyes and other features.3​
  • Some previously irreversible aspects of TED—like tissue swelling and double vision—can improve with Tepezza.​
  • Common side effects are mild to moderate and include muscle cramps, nausea, hair thinning, diarrhea, and fatigue. Rarely, patients with pre-existing inflammatory bowel disease may experience worsening symptoms.4​

Always discuss your medical history and any other health conditions during your assessment.

Why Get Assessed at North Toronto Eye Care?

If you’ve been diagnosed with an overactive thyroid, Graves’ disease, or suspect symptoms of TED, prompt assessment is crucial. Our experienced team uses advanced imaging and clinical criteria to evaluate you and determine if Tepezza is a suitable option. Early intervention offers the best chance for full visual recovery and lasting comfort.

Book your comprehensive thyroid eye disease assessment with North Toronto Eye Care and ask about Tepezza—a proven, non-surgical solution that could help you avoid vision loss and facial changes.

Let us help you protect your vision and restore your confidence.

References

  1. Couch SM. Teprotumumab (Tepezza) for Thyroid Eye Disease. Mo Med. 2022 Jan-Feb;119(1):36-41. PMID: 36033157; PMCID: PMC9312457.
  2. https://www.tepezza.com/about-tepezza/how-does-tepezza-work-on-thyroid-eye-disease
  3. https://www.empr.com/home/news/tepezza-approved-for-thyroid-eye-disease-regardless-of-disease-activity-duration/
  4. https://www.medcentral.com/ophthamology/breakthrough-non-surgical-treatment-can-reverse-thyroid-eye-disease